解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therape...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.11.019
更新日期:2017-02-01 00:00:00
abstract::Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM cells with HPI, through the interplay of the mevalonate and Hippo signa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.020
更新日期:2017-01-28 00:00:00
abstract::Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.042
更新日期:2017-01-28 00:00:00
abstract::Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.020
更新日期:2017-01-01 00:00:00
abstract::Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.017
更新日期:2017-01-01 00:00:00
abstract::As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.030
更新日期:2016-12-28 00:00:00
abstract::Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect sandwich enzyme-linked immunoso...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.031
更新日期:2016-12-28 00:00:00
abstract::The peptide aptamer DUP-1 targets prostate-specific membrane antigen (PSMA)-negative cells, while the RNA aptamer A10-3.2 targets PSMA-positive prostate cancer cells. Moreover, the tumor-suppressor gene phosphatase and tensin homolog (PTEN) and the chemotherapeutic agent doxorubicin (DOX) effectively inhibit prostate ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.003
更新日期:2016-12-28 00:00:00
abstract::Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.012
更新日期:2016-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.017
更新日期:2016-12-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.02.057
更新日期:2016-10-10 00:00:00
abstract::We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.07.034
更新日期:2016-10-10 00:00:00
abstract::Somatic mutations and chromosome instability are hallmarks of genomic aberrations in cancer cells. Aneuploidies represent common manifestations of chromosome instability, which is frequently observed in human embryos and malignant solid tumors. Activation of human endogenous retroviruses (HERV)-derived loci is documen...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.08.001
更新日期:2016-10-10 00:00:00
abstract::Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.07.009
更新日期:2016-10-01 00:00:00
abstract::Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.07.044
更新日期:2016-09-28 00:00:00
abstract::Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.06.017
更新日期:2016-09-28 00:00:00
abstract::Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.12.019
更新日期:2016-09-28 00:00:00
abstract::It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.09.009
更新日期:2016-09-28 00:00:00
abstract::The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.06.019
更新日期:2016-09-28 00:00:00
abstract::Tumor-associated macrophages (TAMs) have important roles in the angiogenesis and tumor immunosuppression of various cancers, including esophageal squamous cell carcinomas (ESCCs). To elucidate the roles of TAMs in ESCCs, we compared the gene expression profiles between human peripheral blood monocyte-derived macrophag...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.06.009
更新日期:2016-09-28 00:00:00
abstract::The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.06.022
更新日期:2016-09-01 00:00:00
abstract::Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk facto...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.07.018
更新日期:2016-09-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.027
更新日期:2016-08-28 00:00:00
abstract::The antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing them with tumor lysate-pulsed dendritic cells (tDCs); this phenomenon has been studied mainly at the population level. Using time-lapse imaging, we examined how CIK cells gather information from tDCs at the single-cell level...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.020
更新日期:2016-08-10 00:00:00
abstract::Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are poorly understood. Through gene expression profiling analysis we found that histone H3K36...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.004
更新日期:2016-08-10 00:00:00
abstract::Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.05.012
更新日期:2016-08-10 00:00:00
abstract::Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcripti...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.010
更新日期:2016-08-01 00:00:00
abstract::Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.040
更新日期:2016-07-28 00:00:00
abstract::In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.029
更新日期:2016-07-10 00:00:00
abstract::Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.022
更新日期:2016-07-10 00:00:00
abstract::The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repe...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.012
更新日期:2016-07-01 00:00:00
abstract::Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC)...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.03.041
更新日期:2016-06-28 00:00:00
abstract::NLRC5, the largest member of nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family, has been reported to regulate immune responses and is associated with chronic inflammatory diseases. However, the biological function of NLRC5 in hepatocellular carcinoma (HCC) has not yet been well demonstrate...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.03.006
更新日期:2016-06-28 00:00:00
abstract::YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.022
更新日期:2016-06-28 00:00:00
abstract::The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.01.024
更新日期:2016-06-01 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.005
更新日期:2016-06-01 00:00:00
abstract::Anticancer properties of chemically synthesized compounds have continuously been optimized for better efficacy and selectivity. Derivatives of heterocyclic compounds are well known to have selective antiproliferative effect against many types of cancer. In this study, we investigated the ability of an indigenously syn...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.028
更新日期:2016-06-01 00:00:00
abstract::We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.041
更新日期:2016-05-28 00:00:00
abstract::Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.040
更新日期:2016-05-28 00:00:00
abstract::The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by d...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.02.050
更新日期:2016-05-28 00:00:00